Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo

Table 1

Distribution and frequencies of NK cells, NK-cell subsets, and myeloid cells in mice with reconstituted human immune system components. Only data from two mouse model systems of human immune system reconstitution are shown. Frequency of NK-cell subsets relates to total NK cells. In vivo administration of human cytokines is reported to lead to up to tenfold increases in targeted cell compartments [22, 52]. *Chijioke et al., unpublished.

	huNSG	huRag2^−/−γ c^−/−
NK cells (CD3^−NKp46^+ or CD3^-CD56^+)	Bone marrow: 0.5–1.5% [52, 54]; Blood: 1–3% [52, 54]; Spleen: 1–3% [52, 54]; Thymus: not reported; Lung: 2–5% [52, 54]; Liver: 3–4.5% [52, 54]	Bone marrow: <0.2% [22]; Blood: <0.5% [22]; Spleen: <0.2% [22]; Thymus: <1% [22]; Lung: not reported; Liver: <0.4% [22]
CD56^brightCD16^− NK cells	Bone marrow: >30% [*]; Blood: 25% [*]; Spleen: 5–10% [54, *]; Thymus: not reported; Liver: 5% [*]	Bone marrow: 10% [22]; Blood: not reported; Spleen: 40% [22]; Thymus: 30% [22]; Liver: not reported
CD56^dimCD16^+ NK cells	Bone marrow: <15% [*]; Blood: 20% [*]; Spleen: 30–40% [54, *]; Thymus: not reported; Liver: 30% [*]	Bone marrow: 90% [22]; Blood: not reported; Spleen: 60% [22]; Thymus: 70% [22]; Liver: not reported
CD56^- NK cells	Bone marrow: <10% [*]; Blood: 30% [*]; Spleen: 30–40% [54, *]; Thymus: not reported; Liver: 40–50% [*]	Bone marrow: % not reported [22]; Blood: not reported; Spleen: % not reported [22]; Thymus: % not reported [22]; Liver: not reported
CD123^+HLA-DR^+ plasmacytoid DCs	Bone marrow: not reported; Spleen: 1–2% [54]	Bone marrow: 1.5–3% [22, 55]; Spleen: <0.5% [55]
CD11c^+HLA-DR^+ myeloid DCs	Bone marrow: 1–3% [56]; Blood: not reported; Spleen: 1–3% [54, 56]	Bone marrow: 1–3% [22, 55]; Blood: 5% [57]; Spleen: <2% [55]
CD141^+HLR-DR^+ myeloid DCs	Spleen: <0,1% [58]	Not reported
CD33^+ myeloid cells	Bone marrow: 5–15% [56]; Blood: 5–10% [56]; Spleen: 5–10% [56]	Bone marrow: 20% [57]; Blood: not reported; Spleen: not reported
CD14^+ monocytes/macrophages	Bone marrow: 6–10% [52, 59]; Blood: 2–5% [52, 60]; Spleen: 1–3% [52, 59]; Lung: 10–20% [52]; Liver: 5–10% [52]	Bone marrow: 2% [57]; Blood: 15% [57]; Spleen: not reported; Lung: not reported; Liver: not reported
CD66^+ granulocytes	Not reported	Bone marrow: 10% [57]; Blood: 5% [57]
CD15^+ neutrophils	Bone marrow: 4% [59]; Spleen: 1% [59]	Not reported

*Chijioke et al., unpublished.