Review Article

Possible Involvement of Tight Junctions, Extracellular Matrix and Nuclear Receptors in Epithelial Differentiation

Figure 2

Models of HNF4 -triggered formation of tight junctions and microvilli in F9 cells. (a) In an undifferentiated state, several junctional proteins are accumulated to premature junctions. (b) HNF4 provokes the formation of junctional complexes and microvilli via induction of expression of occludin [OCLN], claudin-6 [CLDN6], claudin-7 [CLDN7], and ezrin/radixin/moesin-binding phosphoprotein 50 [EBP50].
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(a)
253048.fig.002b
(b)