Herpes Simplex Virus Type-1 (HSV-1) Entry into Human Mesenchymal Stem Cells Is Heavily Dependent on Heparan Sulfate

Figure 4

HSV-1 glycoprotein D (gD) receptors are important for infection of hMSCs. Cultured hMSCs were transfected with an HSV-1 gD expression plasmid (white dot) or with the empty vector pCDNA3.1 (black dot) and infected with HSV-1 at two fold dilution. Reporter enzyme activity, as a measurement of viral entry, was measured with spectrophotometer at 410 nm.