TP53 Status and Response to Treatment in Breast Cancers

Figure 1

The p53 protein structure. The N-terminal region contains the transactivation domain (AA 1–62) and a proline-rich region (residues 63–97) with a role in apoptosis. The central domain (the core domain, AA 102–292) contains specific DNA sites. The C-terminal region includes the tetramerization domain (AA 325–360) and a negative autoregulatory domain. NES signals exist on both N- and C-terminal, whereas NLS signals are located on C-terminal region.