286947.fig.004
Figure 4: Comparison of APA (0.016 mg/kg) and candesartan on BP in SHRs. Intravenous injection of recombinant APA ( ) and candesartan ( ) significantly decreased SBP for 5 d in SHRs. The magnitude of the antihypertensive effects of APA (0.016 mg/kg) and ARB (0.1 mg/kg) was similar. APA (0.016 mg/kg): bolus injection every day for 5 d; candesartan (0.1 mg/kg): continuous infusion by osmotic minipumps for 5 d. * , ** compared with pretreatment period.