About this Journal Submit a Manuscript Table of Contents
Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 294046, 5 pages
http://dx.doi.org/10.1155/2011/294046
Review Article

Analysis of the Pathogenesis of Experimental Autoimmune Optic Neuritis

Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan

Received 31 August 2010; Accepted 13 October 2010

Academic Editor: Oreste Gualillo

Copyright © 2011 Takeshi Kezuka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. A. Lennon, T. J. Kryzer, S. J. Pittock, A. S. Verkman, and S. R. Hinson, “IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel,” Journal of Experimental Medicine, vol. 202, no. 4, pp. 473–477, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. Y. Nakao, H. Yamamoto, E. Arimura et al., “Clinical features of anti-aquaporin 4 antibody-positive optic neuritis in Japanese,” Neuro-Ophthalmology Japan, vol. 25, no. 3, pp. 327–342, 2008. View at Scopus
  3. S. F. Roemer, J. E. Parisi, V. A. Lennon et al., “Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis,” Brain, vol. 130, no. 5, pp. 1194–1205, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. N. T. Potter and P. E. Bigazzi, “Acute optic neuritis associated with immunization with the CNS myelin proteolipid protein,” Investigative Ophthalmology and Visual Science, vol. 33, no. 5, pp. 1717–1722, 1992. View at Scopus
  5. M. K. Storch, A. Stefferl, U. Brehm et al., “Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology,” Brain Pathology, vol. 8, no. 4, pp. 681–694, 1998. View at Scopus
  6. H. Shao, Z. Huang, S. L. Sun, H. J. Kaplan, and D. Sun, “Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57B1/6 mouse,” Investigative Ophthalmology and Visual Science, vol. 45, no. 11, pp. 4060–4065, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. E. Bettelli, M. Pagany, H. L. Weiner, C. Linington, R. A. Sobel, and V. K. Kuchroo, “Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis,” Journal of Experimental Medicine, vol. 197, no. 9, pp. 1073–1081, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. E. Bettelli, D. Baeten, A. Jäger, R. A. Sobel, and V. K. Kuchroo, “Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice,” Journal of Clinical Investigation, vol. 116, no. 9, pp. 2393–2402, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. N. Kaushansky, M.-C. Zhong, N. K. De Rosbo, R. Hoeftberger, H. Lassmann, and A. Ben-Nun, “Epitope specificity of autoreactive T and B cells associated with experimental autoimmune encephalomyelitis and optic neuritis induced by oligodendrocyte-specific protein in SJL/J mice,” Journal of Immunology, vol. 177, no. 10, pp. 7364–7376, 2006. View at Scopus
  10. K. C. O'Connor, K. A. McLaughlin, P. L. De Jager et al., “Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein,” Nature Medicine, vol. 13, no. 2, pp. 211–217, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. R. Meyer, R. Weissert, R. Diem et al., “Acute neuronal apoptosis in a rat model of multiple sclerosis,” Journal of Neuroscience, vol. 21, no. 16, pp. 6214–6220, 2001. View at Scopus
  12. Y. Guan, K. S. Shindler, P. Tabuena, and A. M. Rostami, “Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice,” Journal of Neuroimmunology, vol. 178, no. 1-2, pp. 40–48, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. M. B. Sättler, M. Togni, I. Gadjanski et al., “Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis,” Journal of Neuroimmunology, vol. 193, no. 1-2, pp. 77–86, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. J. Guy, X. Qi, and W. W. Hauswirth, “Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 23, pp. 13847–13852, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Guy, X. Qi, H. Wang, and W. W. Hauswirth, “Adenoviral gene therapy with catalase suppresses experimental optic neuritis,” Archives of Ophthalmology, vol. 117, no. 11, pp. 1533–1539, 1999. View at Scopus
  16. X. Qi, W. W. Hauswirth, and J. Guy, “Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis,” Molecular Vision, vol. 13, pp. 1–11, 2007. View at Scopus
  17. X. Qi, L. Sun, A. S. Lewin, W. W. Hauswirth, and J. Guy, “Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy,” Investigative Ophthalmology and Visual Science, vol. 48, no. 12, pp. 5360–5370, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. X. Qi, A. S. Lewin, L. Sun, W. W. Hauswirth, and J. Guy, “Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis,” Investigative Ophthalmology and Visual Science, vol. 48, no. 2, pp. 681–691, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. J. W. Streilein, “Ocular immune privilege: therapeutic opportunities from an experiment of nature,” Nature Reviews Immunology, vol. 3, no. 11, pp. 879–889, 2003. View at Scopus
  20. Y. Matsunaga, T. Kezuka, and Y. Usui, “Immune privilege ameliorates murine experimental autoimmune optic neuritis induced with myelin/oligodendrocyte glycoprotein,” in Proceedings of the Annual Meeting of Association for Research in Vision and Ophthalmology (ARVO '08), April 2008.