Identification of Missense Mutation (I12T) in the BSND Gene and Bioinformatics Analysis

Table 2

Two-point LOD score results between the locus identified in family and chromosome 1p34.2–p32.1 markers.

Marker	deCode map postion^1	Marshfield map postion^2	Physical map postion^3	LOD score AT 𝜃=
				0.00	0.01	0.05	0.1	0.2	0.3
D1S472	57.95	65.47	37,102,828	−999.99	−0.68	−0.05	0.14	0.20	0.13
D1S186	60.14	67.22	37,900,316	−999.99	−.069	−0.10	0.05	0.10	0.06
D1S432	—	69.86	39,046,164	−1.334	−0.69	−0.18	−0.02	0.03	0.01
D1S1598	63.51	70.41	40,011,183	−1.544	−0.61	−0.09	0.03	0.04	0.00
D1S2706	65.31	71.13	40,741,361	−999.99	−1.34	−0.18	015	0.24	0.14
D1S3721	65.87	72.59	41,395,560	2.027	1.97	1.75	1.49	1.49	0.56
D1S193	66.64	73.21	42,688,369	2.027	1.97	1.75	1.49	0.99	0.56
D1S2713	67.87	73.81	44,182,569	1.726	1.67	1.47	1.24	0.80	0.43
D1S2134	71.29	75.66	47,993,241	1.690	1.66	1.52	1.32	0.91	0.52
D1S1661	72.42	78.25	51,142,551	1.228	1.19	1.06	0.90	0.60	0.33
D1S2652	77.15	80.77	55,178,852	1.319	1.28	1.13	0.96	0.62	0.34
D1S2690	79.63	83.07	56,867,560	2.027	1.97	1.75	1.49	0.99	0.56
D1S2700	83.07	87.31	58,828,955	2.556	2.48	2.21	1.88	1.23	0.66
D1S2770	85.02	88.40	59,442,255	−999.99	−0.26	0.26	0.35	0.29	0.17
D1S1596	—	89.49	59,670,589	−1.55	−0.52	−0.00	0.10	0.08	0.01
D1S2737	85.47	90.58	61,038,037	−999.99	−1.10	0.07	0.40	0.46	0.29
D1S2788	87.25	93.86	61,568,857	−999.99	−2.16	−0.90	−0.46	−0.14	−0.03
D1S230	88.12	95.31	62,314,306	−999.99	−2.16	−0.90	−0.46	−0.14	−0.03
D1S1648	99.62	101.48	73,125,563	−999.99	−2.27	−1.00	−0.55	−0.20	−0.06
D1S1665	99.62	102.02	73,941,402	−999.99	−2.34	−1.04	−0.57	−0.20	−0.06

¹Sex-average Kosambi cM map distances from the deCode genetic map [7].
²Sex-average Kosambi cM map distances from the Marshfield genetic map [17].
³Sequence-based physical map distance in bases according to the Human Genome Project-Santa Cruz (http://genome.ucsc.edu/, Assembly: May 2004).