Etiological Analysis of Neurodevelopmental Disabilities: Single-Center Eight-Year Clinical Experience in South China
Figure 4
Representative MRI findings in different malformations of cortical development (MCD). Figures 4(a) and 4(b) showed severe cortex dysplasia in bilateral parietal lobes and frontal, temporal and occipital lobes, respectively, in the telencephalon of a 5-month-old male with NDD. Figure 4(c) demonstrated typical lissencephaly in a 9-month-old female with Miller-Dieker syndrome. The white matter volume was decreased while the cortex was thick and smooth due to lack of enough sulcation, forming the so-called pachygyria malformation, and the thickened and irregular cortex in Figure 4(d) revealed the cobblestone cortical malformation in a patient with muscle-eye-brain disease.
