BioMed Research International

Research Article

Animal Models of Colitis-Associated Carcinogenesis

Table 1

Summary of CAC in genetically engineered animal models of colitis.


Model	Characteristics	Tumor histology	Tumor location	Incidence of cancer	References

IL-2 x β ₂-M DKO	UC-like	Carcinoma	Rectum, colon	32% adenocarcinoma	Sohn et al., 2001 [41]
IL-10 KO	CD-like duodenitis, colitis	Carcinoma	Colon, rectum	60% adenocarcinoma	Shattuck-Brandt et al., 2000 [42]
RAG2 KO	Induced by infecting with H. hepaticus	Dysplasia, tubular adenoma, carcinoma, adenocarcinoma	Cecum, colon	100% adenocarcinoma	Erdman et al., 2003 [43]
RAG2/Tgfβ1 DKO	Colitis	Dysplasia, adenocarcinoma	Cecum, colon	100% adenocarcinoma	Erdman et al., 2003 [43]
TCRβ/p53 DKO	UC-like	Dysplasia, adenocarcinoma	Ileocecum, cecum	70% adenocarcinoma	Kado et al., 2001 [44]
Gpx1/Gpx2 DKO	Ileocolitis	Dysplasia, adenocarcinoma, signet ring cell carcinoma	Ileum, colon	28% adenocarcinoma	Chu et al., 2004 [45]
G_αi2 KO	UC-like	Carcinoma	Colon	31% adenocarcinoma	Rudolph et al., 1995 [46]
Msh2 KO	HNPCC	Adenoma, adenocarcinoma	Jejunum	38.9% adenocarcinoma	Reitmair et al., 1996 [47]
Msh3 x Msh6 DKO	HNPCC	Adenoma, adenocarcinoma, lymphoma	GI tract	81.3% adenocarcinoma	Edelmann et al., 2000 [48]
Msh6 KO	HNPCC	Adenoma, adenocarcinoma, lymphoma	GI tract	38.5% adenocarcinoma	Edelmann et al., 2000 [48]
Mlh1 KO	HNPCC	Adenomas, adenocarcinomas	GI tract	72.0% tumor incidence 9.36% adenocarcinoma	Edelmann et al., 1999 [49]
Mlh3 KO	HNPCC	Adenomas, adenocarcinomas	GI tract	52% tumor incidence 14% adenocarcinoma	Chen et al., 2005 [50]
Mlh3 x Pms2 DKO	HNPCC	Adenomas, adenocarcinomas	GI tract	42% tumor incidence	Chen et al., 2005 [50]
Msh2^G674A/G674A	HNPCC	Adenocarcinomas	GI tract	19% adenocarcinoma	Lin et al., 2004 [51]
Mlh^G67R/G67R	HNPCC	Adenocarcinoma, adenoma, squamous basal cell carcinoma	GI tract	61% adenocarcinoma	Avdievich et al., 2008 [52]

Abbreviations: CD, Crohn’s disease; DKO, double knockout; GI, gastrointestinal; HNPCC, hereditary nonpolyposis colorectal cancer; KO, knockout; RAG, recombination-activating gene: UC, ulcerative colitis.