Table 2: Summary of CAC in chemically induced colitis models.

ModelsAnimal speciesTreatmentDurationSelected references

CarrageenanRats5%–10% degraded carrageenan in diet, drinking water or by stomach tube2, 6, 9 months or up to 24 monthsAshi et al., 1978 [89] Oohashi et al., 1981 [90] Ishioka et al., 1987 [91] Tobacman, 2001 [92] Benard et al., 2010 [93]

Dextran Sulfate Sodium (DSS)C57Bl/6J0.1%–0.4% DSS60 daysChromik et al., 2007 [94]
C57Bl/6J0.7% DSS15 cycles of: 1 week DSS followed by 10 days waterKim et al., 2010 [95]
C57Bl/6J2.5% DSS12 cycles of: 7 days DSS followed by 10 days waterSeril et al., 2002 [96]
Mice3% DSS9 cycles of: 7 days DSS followed by 14 days waterOkayasu et al., 2002 [97]
C57Bl/6J4% DSS4 cycles of: 4 days DSS followed by 12 days waterCooper et al. 2001 [98]
Wister Rats (Male)5% DSS5–8 cycles of: 4 days DSS followed by 10 days waterKullmann et al., 2001 [99]
Swiss Webster mice5% DSS7 days DSS followed by 14 days water, sacrificed 120 days after the 4th cycleCooper et al. 2000 [100]

DSS & AOMMice (ICR,Balb/c, C57Bl/6J)AOM (10 mg/kg of body weight) & 2% DSS in drinking waterSingle IP AOM injection followed by 1 week 2% DSSTanaka et al., 2003 [101] Rosenberg et al., 2009 [102] Tanaka and Yasui, 2008 [103]

DSS & DMHMice (BALB/c)1 dose of DMH (20 mg/kg of body weight) & 3% DSS in drinking waterSingle IP DMH injection followed by 3 cycles of 3% DSSKohno et al., 2005 [104] Tanaka et al., 2005 [105]

DSS & IronMice (C57Bl/6J)2X Fe or 2X Fe-NAC diet & 0.7%–1% DSS12 or 15 cycles of DSS (1 DSS cycle = 7 days DSS followed by 10 days water)Seril et al., 2002 [96]
Seril et al., 2002 [106]
Seril et al., 2003 [107]
Seril et al., 2006 [108]

Abbreviations: AOM, azoxymethane; DMH, 1,2-dimethylhydrazine; IP, intraperitoneal.