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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 342816, 10 pages
http://dx.doi.org/10.1155/2011/342816
Research Article

Antinociceptive Activity of the Chloroform Fraction of Dioclea virgata (Rich.) Amshoff (Fabaceae) in Mice

1Laboratory of Pharmaceutical Technology, Center of Health Sciences, Federal University of Paraíba-UFPB, 58059-900 João Pessoa, PB, Brazil
2Department of Chemistry, University of Georgia, Athens, GA 30602, USA

Received 4 February 2011; Revised 6 April 2011; Accepted 10 May 2011

Academic Editor: Abdel A. Abdel-Rahman

Copyright © 2011 Vanine Gomes Mota et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute treatment with the chloroform fraction of Dioclea virgata (Rich.) Amshoff (CFDv) in mice produced decreased ambulation and sedation in the behavioral pharmacological screening. Doses of 125 and 250 mg/kg CFDv decreased latency of sleep onset in the test of sleeping time potentiation. In the open field, animals treated with CFDv reduced ambulation and rearing (250 mg/kg), as well as defecation (125; 250 mg/kg). Regarding the antinociceptive activity, CFDv (125, 250, 500 mg/kg) increased latency to first writhing and decreased the number of writhings induced by acetic acid. In the formalin test, CFDv (250 mg/kg) decreased paw licking time in the first and second phases indicating antinociceptive activity that can be mediated both peripherally and at the central level. CFDv did not affect motor coordination until 120 minutes after treatment. CFDv shows psychopharmacological effects suggestive of CNS-depressant drugs with promising antinociceptive activity.