Review Article
Genetic Rodent Models of Amyotrophic Lateral Sclerosis
Table 3
Overview of transgenic mouse models for motor neuron degeneration (atypical or rare FALS and candidate genes).
| Disease | Gene product | Inheritance | Animal | Genetic modification | Reference |
| ALS2 | Alsin | Recessive | Mouse | KO (exon 3) | [50] | | | | | KO (stop codon in exon 3) | [51] | KO (exon 3 and 4) | [52] | KO (exon 4) | [53] | ALS8 | VAPB | Dominant | Mouse | PrP; VAPB P56S | [54] | ALS | Dynactin | Dominant | Mouse | Knock-in G59S p150Glued | [55] | | | | | Thy-1; G59 p150Glued | [56, 57] | CMT2E/1F | Neurofilament-L | Dominant | Mouse | NF-L L394P | [58] | NA | Peripherin | NA | Mouse | overexpression | [59] | NA | Vascular endothelial growth factor | NA | Mouse | VEGFδ/δ | [60] | FTDP-tau | tau | Dominant | Mouse | 4R human tau | [61] | | | | | R406W human tau | [62, 63] | P301L human tau | [64] | G272V, P301S human tau | [65] | V337M human tau | [66] | P301S human tau | [67] |
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PrP: prion promoter, CMT: Charcot-Marie-Tooth, FTDP: frontotemporal dementia with parkinsonism, and NA: not available.
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