Review Article
Modeling Neurological Disorders by Human Induced Pluripotent Stem Cells
Table 2
Summarizing the similarities and differences of ESC and iPSC for disease modeling.
| | hESCs | iPSCs | Reference |
| Source | ICM | Adult somatic cell | [4, 15] | Basic pluripotent characteristics | | | | Alkaline phosphatase activity | Yes | Yes | [4, 15] | Pluripotent genes expression | Yes | Yes | [4, 15] | Pluripotent cell surface markers | Yes | Yes | [4, 15] | In vitro and in vivo multilinage differentiation | Yes | Yes | [4, 15] | Transcriptomic expression | Normal pluripotent gene expression | Pluripotent gene expression but not all genes similar to hESCs and depend on reprogramming technique | [36, 100] | Proteomic expression | Normal proteomic expression | Not all proteomic expression identical to hESCs | [101] | Disease modeling | From PGD diagnosed embryo in IVF clinic | From diagnosed adult patient somatic cell | [88, 102] | Disease-related expression characteristic | Yes | Yes | [88, 102] |
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