Rodent Models for Metabolic Syndrome Research

Table 1

Different rodent models with the signs of metabolic syndrome.

Rodent model	Age (weeks)	Signs of metabolic syndrome shown by rodents							References
		Obesity	Hypertension	Dyslipidaemia	Cardiovascular dysfunction	Impaired glucose tolerance	Fatty liver	Kidney dysfunction
ob/ob mice	4	✓	×	×	×	×	×	U	[33–39]
	12	✓	×	×	×	✓	✓	U
	24	✓	×	×	✓	✓	✓	U
db/db mice	6	✓	×	×	×	×	×	U	[41–44]
	12-13	✓	×	✓	✓	✓	×	U
	20	✓	×	✓	✓	✓	✓	U
ZDF rat	12–15	✓	✓	✓	✓	×	×	×	[47–53]
	20	✓	✓	✓	✓	×	✓	×
	31–47	✓	✓	✓	✓	×	✓	✓
OLETF rats	8	×	×	✓	×	×	×	×	[58–61]
	14	×	✓	✓	×	×	×	×
	20	✓	✓	✓	×	×	×	×
	24	✓	✓	✓	×	✓	×	×
	34	✓	✓	✓	×	✓	✓	×
	40	✓	✓	✓	×	✓	✓	✓
	60–66	✓	✓	✓	✓	✓	✓	✓
Goto-Kakizaki rats	4	×	×	×	×	✓	×	×	[64–67]
	8	×	×	✓	×	✓	✓	×
	20	×	×	✓	✓	✓	✓	×
	60	×	×	✓	✓	✓	✓	✓

This table represents the signs of metabolic syndrome at different ages. The symbols ✓ and × indicate the presence and absence of these signs of metabolic syndrome at that age, respectively, whereas U indicates unavailability of the data. The table indicates that age is an important parameter since some of the signs are developed in very young rodents whereas others take much longer to develop.