Experimentally Approaching the ICU: Monitoring Outcome-Based Responses in the Two-Hit Mouse Model of Posttraumatic Sepsis

Figure 5

Retrospective comparison of circulating glucose, AST, ALT, LDH, and urea in dying (DIE) versus surviving (SUR) animals prior to CLP. 3-month-old female mice were subjected to trauma/hemorrhage prior to CLP. Displayed values were compared between DIE and SUR at −48 h (DIE 𝑛=16, SUR 𝑛=18; AST: DIE 𝑛=6, SUR 𝑛=12), −24 h (DIE 𝑛=23, SUR 𝑛=32; AST: SUR 𝑛=21), 0 h before-CLP (DIE 𝑛=23, SUR 𝑛=32; AST: DIE 𝑛=8, SUR 𝑛=21) and between time points. ^§𝑃<.05 between time points, and *𝑃<.05 between DIE and SUR.

(a)

(b)

(c)

(d)

(e)