Experimentally Approaching the ICU: Monitoring Outcome-Based Responses in the Two-Hit Mouse Model of Posttraumatic Sepsis

Figure 8

Retrospective comparison of circulating glucose, AST, ALT, LDH, and urea in dying (DIE) versus surviving (SUR) animals after-CLP. 3-month-old female mice were subjected to trauma/hemorrhage followed by polymicrobial CLP-induced sepsis. Displayed values were compared between DIE and SUR groups 6 h (DIE 𝑛=23, SUR 𝑛=32; AST: DIE 𝑛=8, SUR 𝑛=20), 24 h (DIE 𝑛=28, SUR 𝑛=34; AST: DIE 𝑛=14, SUR 𝑛=23), 48 h (DIE 𝑛=19, SUR 𝑛=34; AST: DIE 𝑛=9, SUR 𝑛=23), 72 h (DIE 𝑛=12, SUR 𝑛=34; AST: DIE 𝑛=3, SUR 𝑛=23), and 96 h (SUR at least 𝑛=33; AST: SUR 𝑛=23) after-CLP. Dotted lines represent normal values. *𝑃<.05.

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