The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases
Figure 2
Genomic structure of the different members of the Picornaviridae family. The single-stranded, positive-sense polarity RNA genome encodes a single polyprotein, which is different depending on family member [41]. Black arrow, Lpro cleavage site; two asterisk indicate the maturation cleavage between VP4 and VP2; blue arrow, enterovirus 2Apro cleavage site; an asterisk indicates the unknown cellular protease that achieves P1-2A cleavage in hepatovirus; empty arrow, 3Cpro cleavage sites; S, ribosome skipping at Asn-Pro-Gly-Pro site.
