The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases
Figure 3
Schematic representation of eIF4GI and cleavage sites. The boxes indicate binding sites for eIF4A, eIF4E, elF3, Mnk1 kinase and PABP. Arrows indicates the site of cleavage of eIF4GI by PV 2Apro, HIV-1 PR and caspase-3. Cleavage of eIF4GI by PV 2Apro generates a carboxi-terminal polypeptide named p100. These fragments are different from those produced after cleavage by HIV-1 PR and caspase-3.
