Table 1: Mammalian Members of HAT Family.

Mammalian HATs

ClassSubclassHomology to yeastMammalian membersMechanism of catalysisCell localization

AGNAT-familyGcn5 GCN5LTransfer of acetyl group from acetyl-CoA to ε-NH2 group of histone N-tails after the assembly into nucleosomesNucleus
PCAF
MYST-familyEsa1; Sas2; Sas3Tip60
HBOI
MORF
MOZ
CLOCK
NCOAT
MOF
OthersHATI; Elp3; Hpa2; NutIp300/CBP
TFIIIC complex
ACTR/SRC-I
ATF-2

BHat1HAT1Transfer of acetyl group from acetyl-CoA to ε-NH2 group of free histones prior to their deposition on DNA Cytoplasm