Review Article
Physical and Functional HAT/HDAC Interplay Regulates Protein Acetylation Balance
Table 2
Mammalian Members of HDAC Family.
| Mammalian HDACs |
| Class | Homology to yeast | Mammalian members | Mechanism of catalysis | Cell localization |
| I | Rpd3 | HDAC1 | Zn2+ ion dependent | Ubiquitous | HDAC2 | HDAC3 | HDAC8 |
| II | Hda1 | HDAC4 | Zn2+ ion dependent | | HDAC5 | | HDAC7 | Shuttle between | HDAC9 | nucleus and cytoplasm | HDAC6 | | HDAC10 | |
| III | Sir2 | SIRT1 | NAD+ dependent | Nucleus | SIRT2 | Cytoplasm | SIRT3 | Mitochondria | SIRT4 | Mitochondria | SIRT5 | Mitochondria | SIRT6 | Nucleus | SIRT7 | Nucleus |
| IV | HOS3 | HDAC11 | Zn2+ ion dependent | Nucleus |
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