Table 2: Mammalian Members of HDAC Family.

Mammalian HDACs

ClassHomology to yeastMammalian membersMechanism of catalysisCell localization

IRpd3HDAC1Zn2+ ion dependentUbiquitous
HDAC2
HDAC3
HDAC8

IIHda1HDAC4Zn2+ ion dependent
HDAC5
HDAC7Shuttle between
HDAC9nucleus and cytoplasm
HDAC6
HDAC10

IIISir2 SIRT1NAD+ dependent Nucleus
SIRT2Cytoplasm
SIRT3Mitochondria
SIRT4Mitochondria
SIRT5Mitochondria
SIRT6Nucleus
SIRT7Nucleus

IVHOS3 HDAC11Zn2+ ion dependentNucleus