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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 383962, 8 pages
http://dx.doi.org/10.1155/2011/383962
Review Article

Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites

Department of Infectious Diseases, Kyorin University School of Medicine, Tokyo 181-8611, Japan

Received 23 May 2011; Revised 23 August 2011; Accepted 23 August 2011

Academic Editor: Luis I. Terrazas

Copyright © 2011 Mamoru Niikura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Interleukin- (IL-) 10, anti-inflammatory cytokine, is known to inhibit the protective immune responses against malaria parasites and to be involved in exacerbating parasitemia during Plasmodium infection. In contrast, IL-10 is regarded as necessary for suppressing severe pathology during Plasmodium infection. Here, we summarize the role of IL-10 during murine malaria infection, focusing especially on coinfection with lethal and nonlethal strains of malaria parasites. Recent studies have demonstrated that the major sources of IL-10 are subpopulations of CD4+ T cells in humans and mice infected with Plasmodium. We also discuss the influence of innate immunity on the induction of CD4+ T cells during murine malaria coinfection.