Both Basic and Acidic Amino Acid Residues of Are Involved in Triggering Substate of RyR1
Figure 5
Properties of single channel gating in wild-type and mutant IpTxa-modified purified RyR1. (a) Single channel currents of purified RyR1 activated in the presence of wild-type or mutant IpTxa were measured at −30 mV holding potential. The single channel opening is shown as a downward deflection. The recordings of single channel currents were measured at 30 nM wild-type or mutant IpTxa in the cis solution. (b) The plots of of purified RyR1 versus wild-type or mutant IpTxa at various concentrations.
