Table 1: EC50 values (concentration producing 50% of maximum inhibition of spontaneous or agonist-induced contractions) of compound 22 in the isolated bladder, ileum and uterus.

EC50 values (μM)

Effects of compound 22 inBladder
[26]
Ileum
[43]
Uterus
[44]

Spontaneous contractionsn.e.1.254.63

Agonist-induced contractions

 ACh (1 μM)1.255.014.37
 EFSn.e.3.16n.t.
 High k+ (20 mM KCI) 2.510.793.04

n.e.: no effect, n.t.: not tested.