Table 1:
EC
50
values (concentration producing 50% of maximum inhibition of spontaneous or agonist-induced contractions) of compound 22 in the isolated bladder, ileum and uterus.
EC
50
values (
μ
M)
Effects of compound 22 in
Bladder
[
26
]
Ileum
[
43
]
Uterus
[
44
]
Spontaneous contractions
n.e.
1.25
4.63
Agonist-induced contractions
ACh (1
μ
M)
1.25
5.01
4.37
EFS
n.e.
3.16
n.t.
High k
+
(20 mM KCI)
2.51
0.79
3.04
n.e.: no effect, n.t.: not tested.