On Benzofuroindole Analogues as Smooth Muscle Relaxants

Table 1

EC₅₀ values (concentration producing 50% of maximum inhibition of spontaneous or agonist-induced contractions) of compound 22 in the isolated bladder, ileum and uterus.

EC50 values (μM)
Effects of compound 22 in	Bladder; [26]	Ileum; [43]	Uterus; [44]
Spontaneous contractions	n.e.	1.25	4.63
Agonist-induced contractions
ACh (1 μM)	1.25	5.01	4.37
EFS	n.e.	3.16	n.t.
High k^+(20 mM KCI)	2.51	0.79	3.04

n.e.: no effect, n.t.: not tested.