Review Article

Animal Models of Middle Ear Cholesteatoma

Figure 7

Inflammatory response typical of the site of keratin implant at 1 week survival (reproduced with modification with permission from Chole et al. [55]). The irregular surface of the bone (arrows) is suggestive of erosion though few surface osteoclasts are seen at this time (reproduced with modification with permission from Chole et al. [55]). New vessels (v) are evident, and, at higher power (inset, (b)), the remains of keratin debris (k) can be seen surrounded by macrophages, lymphocytes, and giant cells (reproduced with modification with permission from Chole et al. [55]).
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