Long-Term Type 1 Diabetes Enhances In-Stent Restenosis after Aortic Stenting in Diabetes-Prone BB Rats
Figure 4
Long-term diabetes in BBDP rats is associated with enhanced in-stent restenosis 4 weeks after stenting in the abdominal aorta. (a) Photograph of a BeStent 2 bare metal stent used for implantation. The inflation balloon has been removed. (b) Surface area neointima present 28 days after stenting in long-term DM (white bar) and non-DM (black bar) BBDP rats. (c) Mean injury score at 28 days after stenting in long-term DM (white bar) and non-DM (black bar) BBDP rats. Data are expressed as the mean ± SEM (*). Values within bars indicate the number of rats analyzed. DM: long-term diabetic BBDP rats, Non-DM: non-diabetic rats. ((d), (e)) Representative photomicrographs (Lawson staining) of stented abdominal aortas from a thymectomized non-diabetic (non-DM) BBDP rat 28 days after stenting. ((f), (g)) Representative photomicrographs (Lawson staining) of stented abdominal aortas from a diabetic (DM) BBDP rat 28 days after stenting. (e) and (g) are high-power magnifications (magnification ×100) of the framed areas shown in, respectively, (d) and (f) (magnification ×40). a: adventitia; m: media; ni: neointima; s: stent strut.
