Table 1: Comparison of lipid metabolism, atherosclerosis, and cardiac functions between genetically modified mice and WHHLMI rabbits.

Genetically modified miceWHHLMI rabbits

Lipid metabolism
 Major lipoprotein in the bloodX (Chylomicron, VLDL)O (LDL)
 Structural protein in theendogenous lipoproteinX (apoB48)O (apoB100)
 Expression of apoB editing enzymeX (The small intestine, liver)O (The small intestine)
 CETP activity in the bloodX (No)O (Exists)
 Hepatic lipaseX (Released to circulation)O (Bound to vessel membrane)
Atherosclerosis
 The coronary lesionX (Resistant)Δ (Spontaneously develops)
 Composition of the lesionsX (Over accumulation of macrophages)O (Various lesions)
 VLDL receptorX (no expression)O (expression)
Heart
 Electrocardiogram
  Limb leadX (Largely different waveforms)O (Similar to humans)
  Chest leadX (Difficult to monitor)O (Similar to humans)
 Myocardial ion channelX (Ito and IK,slow)O (Ikr and IKs)
 Myocardial fibersX (α-myosin heavy chain)O (β-myosin heavy chain)
Others
Inflammatory markersX (SAP)O (CRP)
The hypocholesterolemic effect of statinsX (Resistant)O (Effective)

O: similar to humans; Δ: partly similar to humans; X: largely different from humans.