Table 2: Drug development using WHHL/WHHLMI rabbits.

Lipid-lowering effect Lipid-lowering effect
AortaCoronary arteries

Cholesterol synthesis inhibitors
 StatinsOX, OO
 Squalene synthesis inhibitorOOO
Anion exchangerOO
Statins + Anion exchangerOOO
MTP inhibitorO
ACAT inhibitorX, OX, OX, O
Antioxidants
 ProbucolOO
 Vitamin EXX, O
Colony stimulating factor
 MCSFX, OO
 GMCSFX, OO
Apo EX, OO
FibrateX
Fish oils, ommega-3 fatty acidsX, OX, O
ThiazolidinedioneXΔΔ
Thiazolidinedione + statinOOO
Antihypertensive
 ACE inhibitorXO
 AT-II receptor antagonistsXO
 Calcium antagonistsXX
 Beta-blockersXX
Gene therapyO

O: effective; Δ: partly effective; X: no effect.
Modified from Shiomi and Ito [8].