424929.fig.006a
(a)
424929.fig.006b
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Figure 6: Representative longitudinal microphotographs of rabbit femoral artery with smooth muscle cell-rich neointima 15 minutes after vascular narrowing. (a) Broad superficial neointimal damage at poststenotic region. Neointimal cell detachment (small arrows) at high magnification. N, neointima; M, media; Ad, adventitia. Large arrow indicates blood flow. (b) Immunohistochemistry to detect von Willebrand factor (VWF, endothelial marker) and smooth muscle actin (SMA, smooth muscle marker) confirms detachment of endothelial and smooth muscle cells at poststenotic region. HE (hematoxylin eosin stain) (from Sumi et al. [45]).