Review Article

A Rabbit Model of Thrombosis on Atherosclerotic Lesions

Figure 7

Mural thrombus growth on neointima after blood flow reduction. Small thrombi (arrows) are induced by balloon injury of normal femoral artery without (a) or with blood flow reduction to 50% (b) or 25% (c). Transmission electron micrograph (d) shows that thrombi consist of aggregated platelets (IEL, internal elastic lamina). Platelet fibrin-rich mural thrombi (arrow heads) are induced by balloon injury of neointima without (e) or with blood flow reduction to 50% (f). Neointimal injury with blood flow reduction to 25% causes occlusive thrombus formation (g). Transmission electron micrograph (h) shows that these thrombi are composed of abundant fibrin strands (f) admixed with platelets (p). Hematoxylin eosin/Victria blue stain (a-c, e-g). (from Yamashita et al. [27] with permission).
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