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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 435271, 12 pages
http://dx.doi.org/10.1155/2011/435271
Research Article

Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin

1Department of Biological Science, The Florida State University, Tallahassee, FL 32306-4295, USA
2Department of Neurobiology, College of Basic Medical Science, Southern Medical University, Guangzhou 510515, China
3Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands
4Department of Biology, American University in Cairo, Cairo 11835, Egypt
5Department of Biomedical Sciences, The Florida State University College of Medicine, Tallahassee, FL 32306, USA
6Institute of Molecular Biophysics, The Florida State University, Tallahassee, FL 32306, USA
7Department of Mathematics, The Florida State University, Tallahassee, FL 32306, USA
8Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
9QIAGEN Inc., Valencia, CA 91355, USA
10Department of Physics, The Florida State University, Tallahassee, FL 32306, USA
11Hitachi Global Storage Technologies, San Jose Research Center, San Jose, CA 95135, USA
12Agilent Technologies Inc., Santa Clara, CA 95051, USA

Received 1 June 2011; Accepted 24 August 2011

Academic Editor: Guy Benian

Copyright © 2011 Fang Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Campion K.P. Loong, Huan-Xiang Zhou, and P. Bryant Chase, “Familial hypertrophic cardiomyopathy related E180G mutation increases flexibility of human cardiac α-tropomyosin,” FEBS Letters, vol. 586, no. 19, pp. 3503–3507, 2012. View at Publisher · View at Google Scholar
  • Campion K. P. Loong, Huan-Xiang Zhou, and P. Bryant Chase, “Persistence Length of Human Cardiac alpha-Tropomyosin Measured by Single Molecule Direct Probe Microscopy,” Plos One, vol. 7, no. 6, 2012. View at Publisher · View at Google Scholar
  • Faizal Z. Asumda, and P. Bryant Chase, “Nuclear cardiac troponin and tropomyosin are expressed early in cardiac differentiation of rat mesenchymal stem cells,” Differentiation, vol. 83, no. 3, pp. 106–115, 2012. View at Publisher · View at Google Scholar
  • Julien Ochala, David S. Gokhin, Isabelle Pénisson-Besnier, Susana Quijano-Roy, Nicole Monnier, Joël Lunardi, Norma B. Romero, and Velia M. Fowler, “Congenital myopathy-causing tropomyosin mutations induce thin filament dysfunction via distinct physiological mechanisms,” Human Molecular Genetics, vol. 21, no. 20, pp. 4473–4485, 2012. View at Publisher · View at Google Scholar
  • Nicolas M. Brunet, Goran Mihajlović, Khaled Aledealat, Fang Wang, Peng Xiong, Stephan von Molnár, and P. Bryant Chase, “Micromechanical Thermal Assays of Ca2+-Regulated Thin-Filament Function and Modulation by Hypertrophic Cardiomyopathy Mutants of Human Cardiac Troponin,” Journal of Biomedicine and Biotechnology, vol. 2012, pp. 1–13, 2012. View at Publisher · View at Google Scholar
  • Campion K.P. Loong, Myriam A. Badr, and P. Bryant Chase, “Tropomyosin flexural rigidity and single Ca2+ regulatory unit dynamics: Implications for cooperative regulation of cardiac muscle contraction and cardiomyocyte hypertrophy,” Frontiers in Physiology, vol. 3, 2012. View at Publisher · View at Google Scholar
  • P. Bryant Chase, Mark P. Szczypinski, and Elliott P. Soto, “Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?,” Journal of Muscle Research and Cell Motility, 2013. View at Publisher · View at Google Scholar
  • Campion K. P. Loong, Aya K. Takeda, Myriam A. Badr, Jordan S. Rogers, and P. Bryant Chase, “Slowed Dynamics of Thin Filament Regulatory Units Reduces Ca2+-Sensitivity of Cardiac Biomechanical Function,” Cellular and Molecular Bioengineering, vol. 6, no. 2, pp. 183–198, 2013. View at Publisher · View at Google Scholar
  • J. Paul Kirwan, and Robert S. Hodges, “Transmission of Stability Information through the N-domain of Tropomyosin Is Interrupted by a Stabilizing Mutation (A109L) in the Hydrophobic Core of the Stability Control Region (Residues 97-118),” Journal of Biological Chemistry, vol. 289, no. 7, pp. 4356–4366, 2014. View at Publisher · View at Google Scholar
  • Nicolas M. Brunet, P. Bryant Chase, Goran Mihajlović, and Brenda Schoffstall, “Ca2+-regulatory function of the inhibitory peptide region of cardiac troponin I is aided by the C-terminus of cardiac troponin T: Effects of familial hypertrophic cardiomyopathy mutations cTnI R145G and cTnT R278C, alone and in combination, on filament sliding,” Archives of Biochemistry and Biophysics, 2014. View at Publisher · View at Google Scholar