Facilitated Cross-Bridge Interactions with Thin Filaments by Familial Hypertrophic Cardiomyopathy Mutations in α-Tropomyosin : Table 1

Table 1: Motility speed-pCa regression parameter estimates for regulated thin filaments containing HcTn and WT or mutant tropomyosin.


	α-GS-Tm	α-GS-Tm	α-GS-Tm	α-GS-Tm
	WT	V95A	D175N	E180G

pCa₅₀		*		*

			*	1*

Speed-pCa data from regulated motility assays (Figure 3) were fit to (4) by nonlinear least squares regression (Methods). Values are regression parameter estimates ±SE. Parameter estimates of pCa₅₀ and that are significantly different from those for α-GS-Tm WT are indicated by *().