IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy
Figure 1
Schema for sample collection. Sera were collected from men with prostate cancer undergoing treatment on three separate clinical trials. Shown are the timing of blood collection and basic schema for these studies. In one study, blood was collected immediately preceding, and at three months following, standard androgen deprivation therapy with a 3-month depot injection of an LHRH agonist. Patients were men () with prostate cancer who had not previously received androgen depriving therapy, and had PSA-recurrent and/or metastatic prostate cancer. In the second study, blood was collected immediately preceding and three months following initiation of treatment with a poxviral vaccine encoding PSA (PSA-TRICOM) [5]. Patients were men () with castrate-resistant metastatic prostate cancer. In the third study, blood was collected immediately preceding, and at three months following, biweekly treatment with a DNA vaccine encoding prostatic acid phosphatase (PAP) [6]. Patients were men () with non-castrate, PSA-recurrent prostate cancer without evidence of metastatic disease.
