IgG Responses to Tissue-Associated Antigens as Biomarkers of Immunological Treatment Efficacy

Figure 4

Structure of Bayesian Belief Network representing selected subset of biomarkers. The structure of the network represents the hierarchy of conditional dependence between features, hence we can identify that the two first degree associates of clinical response are change in IgG responses to BACRP11-321G3 and chromosome 1 gene contig 1. Further, because IgG response to BAC RP11-321G3 is a shared child between PSA decline and IgG response to RP11-738B7 DNA on chromosome 7, IgG response to RP11-738B7 DNA on chromosome 7 still influences the estimate of PSA decline even when IgG response to BAC RP11-321G3 is known.