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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 456076, 9 pages
http://dx.doi.org/10.1155/2011/456076
Research Article

No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis

Laboratory of Pathophysiology, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium

Received 21 April 2011; Revised 14 June 2011; Accepted 4 July 2011

Academic Editor: Yeon-Kyun Shin

Copyright © 2011 Anja Verhulst et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In clinical studies of statins (class of drugs lowering plasma cholesterol levels), transient low-molecular-weight proteinuria was observed. The causes of statin-induced proteinuria in the patient background of those studies (cardiovascular and kidney disease) are multifactorial and, therefore, a matter of debate. In light of this, it seemed interesting to investigate the effect of statins on the urinary protein concentration and proteome in healthy volunteers. Six healthy volunteers were randomly treated with rosuvastatin (40 mg/day) or pravastatin (80 mg/day) in a double-blinded cross-over study. Total urinary protein concentration and the concentration of albumin/retinol-binding protein were analysed, after which the urinary proteome was investigated. From the results described in this study, it was concluded that statins do not induce major changes in the urinary protein concentration/proteome. High variability in the baseline urinary proteome/proteins among volunteers, however, made it very difficult to find subtle (possibly isolated to individuals) effects of statins.