No Evidence for Statin-induced Proteinuria in Healthy Volunteers as Assessed by Proteomic Analysis

Table 1

Inclusion and exclusion criteria of the study.

Inclusion criteria	Exclusion criteria
Male	Treatment with lipid-lowering drugs <1 year prior to the study
Age 25–65 years	Known history of diabetes or fasting glucose level >110 mg/dL
Nonsmoker	Antihypertensive medication
Proteinuria <150 mg/24 hours	Lifeexpectancy <1 year
Dipstick negative hematuria	Pharmacological treatment with inotropes
Blood pressure <135 mm systolic, <85 mm diastolic	Acute or chronic inflammatory process, use of anti-inflammatory drugs, or immunosuppression
Waist circumference <94 cm	Clinically active malignant disease
	Administration of any investigational drug within 30 days preceding the study start and during the study
	Known intolerance to rosuvastatin or other statins
	Acute or chronic liver disease or ALAT >2.0 × upper limit of normal (ULN) at enrolment visit.
	Chronic muscle disease such as dermatomyositis or polymyositis or unexplained creatinine kinase (CK) above 3 × ULN at enrolment
	Uncontrolled hypothyroidism as indicated by a thyroid-stimulating hormone (TSH) >2 × ULN at enrolment
	Renal insufficiency: creatinine >2.0 mg/dL
	Known or suspect alcohol or drug abuse