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Journal of Biomedicine and Biotechnology
Volume 2011 (2011), Article ID 468705, 9 pages
Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells: In Vitro and In Vivo Studies
1Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
2Department of Internal Medicine and Gastroenterology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Received 7 July 2011; Accepted 16 September 2011
Academic Editor: Herman S. Cheung
Copyright © 2011 Wanda Lattanzi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. A. Zuk, M. Zhu, P. Ashjian et al., “Human adipose tissue is a source of multipotent stem cells,” Molecular Biology of the Cell, vol. 13, no. 12, pp. 4279–4295, 2002.
- A. J. Katz, A. Tholpady, S. S. Tholpady, H. Shang, and R. C. Ogle, “Cell surface and transcriptional characterization of human adipose-derived adherent stromal (HADAS) cells,” Stem Cells, vol. 23, no. 3, pp. 412–423, 2005.
- N. Saulnier, M. A. Puglisi, W. Lattanzi et al., “Gene profiling of bone marrow- and adipose tissue-derived stromal cells: a key role of Kruppel-like factor 4 in cell fate regulation,” Cytotherapy, vol. 13, no. 3, pp. 329–340, 2011.
- P. A. Zuk, M. Zhu, H. Mizuno et al., “Multilineage cells from human adipose tissue: implications for cell-based therapies,” Tissue Engineering, vol. 7, no. 2, pp. 211–228, 2001.
- F. Guilak, K. E. Lott, H. A. Awad et al., “Clonal analysis of the differentiation potential of human adipose-derived adult stem cells,” Journal of Cellular Physiology, vol. 206, no. 1, pp. 229–237, 2006.
- N. Saulnier, W. Lattanzi, M. A. Puglisi et al., “Mesenchymal stromal cells multipotency and plasticity: induction toward the hepatic lineage,” European Review for Medical and Pharmacological Sciences, vol. 13, supplement 1, pp. 71–78, 2009.
- C. Parrilla, W. Lattanzi, A. R. Fetoni, F. Bussu, E. Pola, and G. Paludetti, “Ex vivo gene therapy using autologous dermal fibroblasts expressing hLMP3 for rat mandibular bone regeneration,” Head and Neck, vol. 32, no. 3, pp. 310–318, 2010.
- W. Lattanzi, C. Parrilla, A. Fetoni et al., “Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models,” Gene Therapy, vol. 15, no. 19, pp. 1330–1343, 2008.
- R. Tabakman, H. Jiang, I. Shahar, H. Arien-Zakay, R. A. Levine, and P. Lazarovici, “Neuroprotection by NGF in the PC12 in vitro OGD model: involvement of mitogen-activated protein kinases and gene expression,” Annals of the New York Academy of Sciences, vol. 1053, pp. 84–96, 2005.
- Z. Xu, D. Cawthon, K. A. McCastlain et al., “Selective alterations of transcription factors in MPP+-induced neurotoxicity in PC12 cells,” NeuroToxicology, vol. 26, no. 4, pp. 729–737, 2005.
- R. Businaro, S. Leone, C. Fabrizi et al., “S100B protects LAN-5 neuroblastoma cells against Aβ amyloid-induced neurotoxicity via RAGE engagement at low doses but increases Aβ amyloid neurotoxicity at high doses,” Journal of Neuroscience Research, vol. 83, no. 5, pp. 897–906, 2006.
- W. Lattanzi, C. Bernardini, C. Gangitano, and F. Michetti, “Hypoxia-like transcriptional activation in TMT-induced degeneration: microarray expression analysis on PC12 cells,” Journal of Neurochemistry, vol. 100, no. 6, pp. 1688–1702, 2007.
- C. Bernardini, W. Lattanzi, R. Businaro et al., “Transcritpional effects of S100B on neuroblastoma cells: perturbation of cholesterol homeostasis and interference on the cell cycle,” Gene Expression, vol. 14, no. 6, pp. 345–359, 2010.
- A. Chiarini, U. Armato, R. Pacchiana, and I. D. Pra, “Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions,” Proteomics, vol. 9, no. 7, pp. 1850–1860, 2009.
- Q. Schwarz and C. Ruhrberg, “Neuropilin, you gotta let me know: should I stay or should I go?” Cell Adhesion and Migration, vol. 4, no. 1, pp. 61–66, 2010.
- D. L. Benson and H. Tanaka, “N-cadherin redistribution during synaptogenesis in hippocampal neurons,” Journal of Neuroscience, vol. 18, no. 17, pp. 6892–6904, 1998.
- M. Kadowaki, S. Nakamura, O. Machon, S. Krauss, G. L. Radice, and M. Takeichi, “N-cadherin mediates cortical organization in the mouse brain,” Developmental Biology, vol. 304, no. 1, pp. 22–33, 2007.
- A. Nieoullon, B. Canolle, F. Masmejean, B. Guillet, P. Pisano, and S. Lortet, “The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?” Journal of Neurochemistry, vol. 98, no. 4, pp. 1007–1018, 2006.
- J. Arikkath, “N-cadherin: stabilizing synapses,” Journal of Cell Biology, vol. 189, no. 3, pp. 397–398, 2010.
- K. Sakai, O. Tiebel, M. C. Ljungberg et al., “A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins,” Brain Research, vol. 1276, no. C, pp. 11–21, 2009.
- T. A. Kim, J. Lim, S. Ota et al., “NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation,” Journal of Cell Biology, vol. 141, no. 3, pp. 553–566, 1998.
- G. Mudò, A. Bonomo, V. Di Liberto, M. Frinchi, K. Fuxe, and N. Belluardo, “The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain,” Journal of Neural Transmission, vol. 116, no. 8, pp. 995–1005, 2009.
- C. A. Ingraham, L. Wertalik, and N. F. Schor, “Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress,” Pediatric Research, vol. 69, no. 4, pp. 279–284, 2011.
- A. P. M. de Brouwer, H. van Bokhoven, S. B. Nabuurs, W. F. Arts, J. Christodoulou, and J. Duley, “PRPS1 mutations: four distinct syndromes and potential treatment,” American Journal of Human Genetics, vol. 86, no. 4, pp. 506–518, 2010.
- H. J. Kim, K. M. Sohn, M. E. Shy et al., “Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (CMTX5),” American Journal of Human Genetics, vol. 81, no. 3, pp. 552–558, 2007.
- Y. Miyamae, J. Han, K. Sasaki, M. Terakawa, H. Isoda, and H. Shigemori, “3,4,5-tri-O-caffeoylquinic acid inhibits amyloid β-mediated cellular toxicity on SH-SY5Y cells through the upregulation of PGAM1 and G3PDH,” Cytotechnology, vol. 63, no. 2, pp. 191–200, 2011.
- S. A. Hardy, D. J. Maltman, and S. A. Przyborski, “Mesenchymal stem cells as mediators of neural differentiation,” Current Stem Cell Research and Therapy, vol. 3, no. 1, pp. 43–52, 2008.
- W. Xing, D. Zhimei, Z. Liming et al., “IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats,” Stem Cells, vol. 27, no. 2, pp. 478–488, 2009.
- L. Zhao, X. Wei, Z. Ma et al., “Adipose stromal cells-conditional medium protected glutamate-induced CGNs neuronal death by BDNF,” Neuroscience Letters, vol. 452, no. 3, pp. 238–240, 2009.
- B. Tan, Z. Luan, X. Wei et al., “AMP-activated kinase mediates adipose stem cell-stimulated neuritogenesis of PC12 cells,” Neuroscience, vol. 181, pp. 40–47, 2011.
- D. X. Qian, H. T. Zhang, X. Ma, X. D. Jiang, and R. X. Xu, “Comparison of the efficiencies of three neural induction protocols in human adipose stromal cells,” Neurochemical Research, vol. 35, no. 4, pp. 572–579, 2010.
- J. Sanchez-Ramos, S. Song, F. Cardozo-Pelaez et al., “Adult bone marrow stromal cells differentiate into neural cells in vitro,” Experimental Neurology, vol. 164, no. 2, pp. 247–256, 2000.
- N. Bertani, P. Malatesta, G. Volpi, P. Sonego, and R. Perris, “Neurogenic potential of human mesenchymal stem cells revisited: analysis by immunostaining, time-lapse video and microarray,” Journal of Cell Science, vol. 118, no. 17, pp. 3925–3936, 2005.
- K. Mareschi, M. Novara, D. Rustichelli et al., “Neural differentiation of human mesenchymal stem cells: evidence for expression of neural markers and eag K+ channel types,” Experimental Hematology, vol. 34, no. 11, pp. 1563–1572, 2006.
- A. Cardozo, M. Ielpi, D. Gómez, and P. Argibay, “Differential expression of Shh and BMP signaling in the potential conversion of human adipose tissue stem cells into neuron-like cells in vitro,” Gene Expression, vol. 14, no. 6, pp. 307–319, 2010.
- S. Jang, H. H. Cho, Y. B. Cho, J. S. Park, and H. S. Jeong, “Functional neural differentiation of human adipose tissue-derived stem cells using bFGF and forskolin,” BMC Cell Biology, vol. 11, article 25, 2010.
- G. Lepski, C. E. Jannes, B. Strauss, S. K. N. Marie, and G. Nikkhah, “Survival and neuronal differentiation of mesenchymal stem cells transplanted into the rodent brain are dependent upon microenvironment,” Tissue Engineering—Part A, vol. 16, no. 9, pp. 2769–2782, 2010.
- P. A. Zuk, “The adipose-derived stem cell: looking back and looking ahead,” Molecular Biology of the Cell, vol. 21, no. 11, pp. 1783–1787, 2010.
- T. Kondo, A. J. Matsuoka, A. Shimomura et al., “Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3,” Stem Cells, vol. 29, no. 5, pp. 836–846, 2011.
- Y. L. Yu, R. H. Chou, L. T. Chen et al., “EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling,” Journal of Biological Chemistry, vol. 286, no. 11, pp. 9657–9667, 2011.
- E. Garbayo, A. P. Raval, K. M. Curtis et al., “Neuroprotective properties of marrow-isolated adult multilineage-inducible cells in rat hippocampus following global cerebral ischemia are enhanced when complexed to biomimetic microcarriers,” Journal of Neurochemistry, vol. 119, no. 5, pp. 972–988, 2011.
- J. Y. Lim, S. I. Park, S. M. Kim, et al., “Neural differentiation of brain-derived neurotrophic factor-expressing human umbilical cord blood-derived mesenchymal stem cells in culture via TrkB-mediated ERK and β-catenin phosphorylation and following transplantation into the developing brain,” Cell Transplantion. In press.
- D. Y. Wang, S. C. Wu, S. P. Lin, S. H. Hsiao, T. W. Chung, and Y. Y. Huang, “Evaluation of transdifferentiation from mesenchymal stem cells to neuron-like cells using microfluidic patterned co-culture system,” Biomedical Microdevices, vol. 13, no. 3, pp. 517–526, 2011.
- S. K. Kang, D. H. Lee, Y. C. Bae, H. K. Kim, S. Y. Baik, and J. S. Jung, “Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats,” Experimental Neurology, vol. 183, no. 2, pp. 355–366, 2003.
- S. T. Lee, K. Chu, K. H. Jung et al., “Slowed progression in models of Huntington disease by adipose stem cell transplantation,” Annals of Neurology, vol. 66, no. 5, pp. 671–681, 2009.
- S. Leu, Y. C. Lin, C. M. Yuen et al., “Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats,” Journal of Translational Medicine, vol. 8, article no. 63, 2010.
- Y. Ikegame, K. Yamashita, S. I. Hayashi et al., “Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy,” Cytotherapy, vol. 13, no. 6, pp. 675–685, 2011.
- H. T. Zhang, J. Luo, L. S. Sui et al., “Effects of differentiated versus undifferentiated adipose tissue-derived stromal cell grafts on functional recovery after spinal cord contusion,” Cellular and Molecular Neurobiology, vol. 29, no. 8, pp. 1283–1292, 2009.
- D. Arboleda, S. Forostyak, P. Jendelova et al., “Transplantation of predifferentiated adipose-derived stromal cells for the treatment of spinal cord injury,” Cellular and Molecular Neurobiology, vol. 31, no. 7, pp. 1113–1122, 2011.
- G. C. Kopen, D. J. Prockop, and D. G. Phinney, “Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 19, pp. 10711–10716, 1999.
- S. Dhar, E. S. Yoon, S. Kachgal, and G. R. D. Evans, “Long-term maintenance of neuronally differentiated human adipose tissue-derived stem cells,” Tissue Engineering, vol. 13, no. 11, pp. 2625–2632, 2007.