Table 1: Selected ATSC-specific upregulated genes involved in neurospecific functions ( ).

Gene symbolGene bankGene nameNeurospecific functionsProcessReferences
protectiondevelopmenttrophismmetabolism

SLC1A1NM_004170.5Solute carrier family 1, member 1+Protection against glutamate neurotoxicity[18]
CDH2NM_001792.3Cadherin 2, type 1, N-cadherin (neuronal)+Pre-to-postsynaptic adhesion neuronal migration Axonogenesis synapse assembly[19]
CELF2NM_001025077.2CUG triplet repeat, RNA binding protein 2++Motor neuron survival splicing control during development[7]
VLDLRNM_003383.3Very low density lipoprotein receptor+++Protection against hypoxia and glucose starvation Nervous system development lipid uptake in neurons and astrocytes[20]
NRP1NM_003873Neuropilin 1+++Cell survival axon guidance Migration and invasion[15]
NGFBNM_002506.2Nerve growth factor, beta polypeptide+Neuron differentiation nerve growth[9]
ENC1NM_003633.2Ectodermal-neural cortex++Anti-apoptotic nervous system development[21]
GCH1NM_000161.2GTP cyclohydrolase 1++Protection from brain damaging events secreted by astrocyte[14]
FGF2NG_012449.1Fibroblast growth factor 2++Neurogenesis migration[22]
NDNNM_002487.2Necdin homolog (mouse)++Protects neuron from oxidant stress Neuron development glial cell migration[23]
PRPS1NM_002764.3Phosphoribosyl pyrophosphate synthetase 1++Purine synthesis nervous system development[24, 25]
PGAM1NM_002629.2Phosphoglycerate mutase 1 (brain)++Regulation of energy metabolism neuroprotection against Aß-toxicity[26]