Effects of Clofibrate on Salt Loading-Induced Hypertension in Rats

Table 4

Urinary variables in experimental groups.

Groups	Control	Clofibrate	Salt	Salt + clofibrate
Uv, mL/100 g	2.60±0.33	3.20±0.43	10.01±1.00^∗∗	^+15.06±1.11^∗∗
UNaV, mEq/100 g	0.15±0.01	0.16±0.02	2.76±0.42^∗	^+7.85±1.04^∗
UKV, mEq/100 g	0.34±0.03	0.35±0.03	0.47±0.06	^+0.77±0.08^∗
UCaV, g/100 g	0.58±0.26	0.73±0.16	9.10±1.52^∗	^+5.85±0.15^∗
CrC, mL/min.100 g	0.42±0.02	0.43±0.02	0.52±0.03^∗	0.41±0.03
UCrV, mg/100 g	3.28±0.13	3.15±0.18	3.54±0.07	3.26±0.19
UproteinV, mg/100 g	33.51±2.25	22.74±1.60^∗	61.20±4.76^∗	^+43.22±2.30^∗
UisoprostaneV, 𝜇g/100 g	3.85±0.68	3.57±1.3	7.40±0.72^∗	8.22±3.18^∗
UNOxV, nM/100 g	20.5±1.4	22±1.5	45±1.6^∗∗	40±1.0^∗∗
UETV, pg/100 g	2.41±1.17	2.19±0.48	19.60±7.31^∗∗	16.09±3.28^∗∗
UVPV, pg/100 g	123.44±7.06	121.75±8.09	181.04±8.36^∗	172.05±10.71^∗

Data expressed as means ± s.e.m. Uv, diuresis; UNaV, natriuresis; UKV, kaliuresis; UcaV, calciuresis; CrC, creatinine clearance; UCrV, total creatinine excretion; UproteinV, proteinuria; UisoprostaneV, total isoprostanes excretion; UNOxV, total nitrates and nitrites excretion; UETV, total endothelin excretion; UVPV, total vasopressin excretion. All data are referred to 24 h. ^∗𝑃<.05, ^∗∗𝑃<.01 versus control group; +𝑃<.05, ++𝑃<.01 versus salt group.