474632.fig.001
Figure 1: The search for drug response-related miRNAs began with data acquisition from several independent databases. Drug response data for lung cancer cell lines (LCCLs) was integrated independently with copy number and expression data, and unique filtering criteria were applied. The integration of all three dimensions applied further filtration criteria, and the remaining miRNAs underwent predicted target analysis. The resulting mRNA target expression was anticorrelated with miRNA expression, and cellular functions of the final mRNA target list were derived by Ingenuity Pathway Analysis.