474632.fig.004
Figure 4: Heatmap visualization of the miRNA expression of the 254 miRNAs (represented by 292 unique probes) that passed expression filtering criteria for the 21 most sensitive (yellow bar, low IC50) and 21 most resistant (blue bar, high IC50) to drug HKI-272. In total, 30 miRNAs were found to be significantly differentially expressed between the most sensitive and resistant lung cancer cell lines (LCCLs, orange bar). For this visualization, since a value of 4 represented no expression, all expression values were subtracted by 4 such that baseline expression would be shown as 0 (black).