479135.fig.007a
(a)
479135.fig.007b
(b)
479135.fig.007c
(c)
479135.fig.007d
(d)
Figure 7: Obscurin depletion leads to marked reduction in localization of -dystroglycan and dystrophin to the myotendinous junction. -dystroglycan ( -DG) (a), (b) and dystrophin (c), (d) are abundant at the myotendinous junctions (MTJ) in control (a), (c) but not obscurin morphant embryos (b), (d). Note that in the obscurin-depleted embryos, -DG and dystrophin are not noted even in the disorganized MTJs of the targeted embryos suggesting a specific destabilization of dystrophin-associated glycoprotein complex (DGC) in response to decreased obscurin expression.