Obscurin Depletion Impairs Organization of Skeletal Muscle in Developing Zebrafish Embryos
Figure 7
Obscurin depletion leads to marked reduction in localization of -dystroglycan and dystrophin to the myotendinous junction. -dystroglycan (-DG) (a), (b) and dystrophin (c), (d) are abundant at the myotendinous junctions (MTJ) in control (a), (c) but not obscurin morphant embryos (b), (d). Note that in the obscurin-depleted embryos, -DG and dystrophin are not noted even in the disorganized MTJs of the targeted embryos suggesting a specific destabilization of dystrophin-associated glycoprotein complex (DGC) in response to decreased obscurin expression.
