Animal Models of Cardiovascular Diseases

Table 3

Current procedures for inducing AAA in animals.

Species	AAA models
Murine	Calcium Chloride [56].
	Elastase infusion [57].
	Angiotensin-II-infused AAA: used in hyperlipidemic (ApoE−/− or LDLR−/−) male mice or in wild-type C57BL/6 mice in conjunction with repeated administration of neutralizing TGF-β antibodies [50].
	Decellularized xenografts: grafting of abdominal aortic extracellular matrix from one species to a compatible recipient of a different species [58].
	Spontaneous [59].
Rabbit	Elastase-induced AAA: similar to the murine model [60], also applicable to the carotid artery [61].
	Calcium chloride [62].
Pig	Surgical model: dilatation of the infrarenal aorta with an angioplasty balloon followed by infusion of pancreatic porcine elastase [63].