BioMed Research International / 2011 / Article / Tab 4 / Review Article
Animal Models of Cardiovascular Diseases Table 4 Current procedures for inducing heart damage in animals.
Species Heart failure models Murine Myocardial damage Chemical: isoproterenol administration [106 ]. Electrical: overlapping burns [107 ]. Surgical: coronary artery ligation [105 ].Ischemia Reperfusion: Transient occlusion of the left coronary artery [108 ].Cryoinfarction: cryo-injuries to the epicardium [109 ].Pressure overload: aortic constriction and banding. Aortic stenosis [110 , 111 ].Transgenic models of dilated cardiomyopathy: mutation of cardiac α -actin protein [112 ]. Rabbit Spontaneous: WHHLMI rabbits [113 ].Coronary artery occlusion: similar to the murine model, also applicable to the carotid artery. This is an excellent model for testing endovascular therapies [114 ].Pressure overload: aortic banding [115 ], valvular stenosis [116 ]. Dog Microembolization [117 ].Tachycardia: ventricular pacing [118 ].Aortic stenosis [119 ]. Pig Surgical model: balloon occlusion of coronary arteries [120 ].Tachycardia: pacing-induced supraventricular tachycardia [121 ].