The IQ Motif is Crucial for Ca _v 1.1 Function

Figure 5

Ca_v1.1_AA is targeted to T-SR junctions. Confocal images of colocalization of either YFP-Ca_v1.1 (a) or YFP-Ca_v1.1_AA (b) green fluorescence and immunolabeled RyR1 ((d) and (e)) red fluorescence in dysgenic myotubes. (g) and (h) represent overlay of (a) and (d), and (b) and (e), respectively. The control dysgenic myotube (no Ca_v1.1) immunolabeled without (c) and with (f) primary Ab(34C). Bar, 20 μm.

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