Review Article
Modulation of Acetylation: Creating a Pro-survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock
Table 1
Classification of HDACs and selected HDACIs.
| HDAC Class | HDAC isoforms | Localization of HDAC | Specific HDAC inhibitors | Nonspecific HDAC inhibitors | References | |
| Class I | HDAC1 | Nucleus | MS-275, FK-228 | TSA | [9, 16] | | (Zn-dependent) | HDAC2 | Nucleus | FK-228, apicidin | SAHA | | | HDAC3 | Nucleus | MS-275, Apicidin | Butyrate | | | HDAC8 | Nucleus | | Valproic acid | |
| Class IIa | HDAC4 | Nuc/Cyt | | TSA SAHA Butyrate Valproic acid | [9, 16] | | (Zn-dependent) | HDAC5 | Nuc/Cyt | | | | HDAC7 | Nuc/Cyt | | | | HDAC9 | Nuc/Cyt | | |
| Class IIb | HDAC6 | Mainly Cyt | Tubacin | TSA SAHA | [16] | | (Zn-dependent) | HDAC10 | Mainly Cyt | | |
| Class III | SIRT1 | Nuc/Cyt | Suramin | Nicotinamide | [9, 17] | | (NAD-dependent) | SIRT2 | Nuc/Cyt | Suramin, AGK2 | | | SIRT3 | Nuc/Mitoch | | | | SIRT4 | Mitochondria | | | | SIRT5 | Mitochondria | Suramin | | | SIRT6 | Nucleus | | | | SIRT7 | Nucleus | | |
| Class IV (Zn-dependent) | HDAC11 | Nuc/Cyt | | TSA SAHA | [16] | |
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