A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration
Figure 2
Representative DAPI-labeled sections containing the dentate gyrus granule cell layer in a control (a) and an adrenalectomy (ADX) rat (b) after 10 weeks of degeneration. (c) By 10 weeks, ADX rats had lost approximately one-third of the volume of the dentate gyrus granule cell layer when compared to adrenally intact controls. (d) Cell counts using the optical fractionator revealed a loss of roughly half of the dentate gyrus granule cells at the same time point. *indicates significant difference; error bars represent standard error of the mean (adapted from [29]).
