A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration
Figure 6
(a) Our alternating treatment of enrichment and wheel running significantly increased the number of doublecortin (DCX) positive cells in the dentate gyrus of adrenalectomy (ADX) and control rats. (b) Chronic ADX significantly reduced the volume of the dentate gyrus granule cell layer. Most importantly, a combination of six weeks of enriched housing significantly increased the volume of the dentate gyrus granule cell layer in ADX rats, compared to their home cage counterparts. Error bars represent standard error of the mean.
