A Novel Animal Model of Hippocampal Cognitive Deficits, Slow Neurodegeneration, and Neuroregeneration

Figure 7

The experimental time course. Bilateral adrenalectomy (ADX) is conducted at the onset of the experiment. The granule cell layer of the dentate gryus degenerates significantly over the following ten weeks, during which rats remain in their homecages. A subset of ADX rats are exposed to a number of different treatment strategies, after which behavioural and electrophysiological measures can be taken. Upon completion of the experiment, rats are perfused and the granule cell layer is assessed using immunohistochemistry and unbiased stereological techniques.