Current Concepts: Mouse Models of Sjögren's Syndrome

Table 1

Important criterion for an ideal primary SjS mouse model.

	Features
Etiology	Unknown (possible viral exposure)
Clinical	Xerostomia Keratoconjunctivitis sicca
Histological	Polyclonal lymphocytic infiltrations in the salivary and lacrimal glands Lymphocytic focus, >50 mononuclear cells/mm^2 (CD4^+>CD8^+)Monoclonal B cell proliferation Progressive destruction of the acinar and ductal cells
Serological	Hypergammaglobulinemia Anti-SSA/Ro and anti-SSB/La autoantibodiesAnti-α-fodrin autoantibody Rheumatoid factor Antinuclear antibodiesAnti-type 3 acetylcholine muscarinic receptor
Additional organ involvement	Heart, blood vessels, lungs, liver, pancreas, stomach, kidneys, bladder, thyroid gland (secondary SjS)
Immunobiology	Diminished apoptosis of lymphocytes Abnormal MHC expression, H2^+-glandular ductal epithelium Epithelial cell expression of Fas/FasL
Other	9 : 1 female : male ratio Disease presents in absence of other rheumatic diseases