Table 1: Important criterion for an ideal primary SjS mouse model.

Features

EtiologyUnknown (possible viral exposure)

ClinicalXerostomia Keratoconjunctivitis sicca

HistologicalPolyclonal lymphocytic infiltrations in the salivary and lacrimal glands Lymphocytic focus, mononuclear cells/mm2 ( )Monoclonal B cell proliferation Progressive destruction of the acinar and ductal cells

SerologicalHypergammaglobulinemia Anti-SSA/Ro and anti-SSB/La autoantibodiesAnti-α-fodrin autoantibody Rheumatoid factor Antinuclear antibodiesAnti-type 3 acetylcholine muscarinic receptor

Additional organ involvementHeart, blood vessels, lungs, liver, pancreas, stomach, kidneys, bladder, thyroid gland (secondary SjS)

ImmunobiologyDiminished apoptosis of lymphocytes Abnormal MHC expression, H2+-glandular ductal epithelium Epithelial cell expression of Fas/FasL

Other9 : 1 female : male ratio Disease presents in absence of other rheumatic diseases