Table 2: Primary and secondary SjS mouse models.

Type of SjSMouse ModelSecondary to

PrimaryAec1Aec2
NOD.B10-H2b
NFS/sld
IQI/Jic
CAII immunization
PI3K K.O.
ID3 K.O.
Ar K.O.
Ro immunization
Aly/aly

SecondaryNODAutoimmune diabetes
NOD.H2h4Autoimmune thyroiditis
MRL/lprRA, SLE
GVHRSLE
BAFF TgSLE
IL-12 TgSLE
IL-14α TgSLE
MCMVSLE
HTLV-1 tax TgRA [30]
TGF-β1 K.O.SLE [31]
IL-6 TgIL-10 TgPBC [32]SLE/Neuropathy
TSP-1 K.O.IBS

K.O.: knockout; Tg: transgenic; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; PBC: primary biliary cirrhosis; IBS: inflammatory bowel disease.