Review Article
Current Concepts: Mouse Models of Sjögren's Syndrome
Table 2
Primary and secondary SjS mouse models.
| | Type of SjS | Mouse Model | Secondary to |
| | Primary | Aec1Aec2 | — | | NOD.B10-H2b | — | | NFS/sld | — | | IQI/Jic | — | | CAII immunization | — | | PI3K K.O. | — | | ID3 K.O. | — | | Ar K.O. | — | | Ro immunization | — | | Aly/aly | — |
| | Secondary | NOD | Autoimmune diabetes | | NOD.H2h4 | Autoimmune thyroiditis | | MRL/lpr | RA, SLE | | GVHR | SLE | | BAFF Tg | SLE | | IL-12 Tg | SLE | | IL-14α Tg | SLE | | MCMV | SLE | | HTLV-1 tax Tg | RA [30] | | TGF-β1 K.O. | SLE [31] | | IL-6 TgIL-10 Tg | PBC [32]SLE/Neuropathy | | TSP-1 K.O. | IBS |
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K.O.: knockout; Tg: transgenic; SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; PBC: primary biliary cirrhosis; IBS: inflammatory bowel disease.
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